Pancreatic Cancer

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Location of the Pancreas1

  1.  As noted above (left), the pancreas is a tapered, elongated gland located behind the stomach. 

  2.   Introduction to Pancreatic Adenocarcinoma4

  3.  Background2

  4.  Etiologic considerations:

     

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    References

    1. A.D.A.M resource:  Medical Encyclopedia http://www.nlm.nih.gov/medlineplus/ency/imagepages/1090.htm.

    2. McPhee, SJ Disorders of the Exocrine Pancreas, Chapter 15, in Pathophysiology of Disease:  An Introduction to Clinical Medicine, 5th Editions (McPhee, SJ and Ganong, WF, eds), The McGraw-Hill Companies, Inc, 2006. on-line edition.

    3. Sun W and Haller D Pancreatic, Gastric, and Other Gastrointestinal Cancers, Chapter 201, in ACP Medicine 2004-2005 edition (Dale DC and Federman DD, editors) WebMD, New York, 2004, pp.2432-2444.

    4. Drebin JA, Sun W, Metz JM, Furth EE Carcinoma of the Pancreas in Abeloff's Clinical Oncology, 4th Edition, (Abeoff, MD, Armitage, JO, Niederhuber, JE, Kastan MB, and McKenna WG, eds) Churchill Livingsone-Elsevier,2008, pp 1595-1611.

    5. Lipkin S Research Interests http://www.healthaffairs.uci.edu/biochem/faculty/lipkin.html .

    6. KRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [ Homo sapiens ]  Entrez Gene, updated 02-Aug-2008, http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=3845

    7. Zubk KM Eng C Hamartomatous polyposis syndromes Nature Clinical Practice Gastroenterology & Hepatology (2007) 4, 492-502 (http://www.nature.com/ncpgasthep/journal/v4/n9/full/ncpgasthep0902.html); figure attribution:  Bronner M (2003) Gastrointestinal inherited polyposis syndromes. Mod Path 16: 359–365.

    8. Hruban RH Pancreatic Cancer: From Genes to Patient Care, Journal of Gastrointestinal Surgery, 5(6), 2001, pp.583-587.

    9. Royal RE, Wolff RA, Crane CH Pancreatic Cancer in Cancer:  Principles &  Practice of Oncology (Devita Jr VT, Lawrence TS, Rosengerg SA, eds) Volters Kluwer, Lippincott Williams & Wilkins, Philadelphia, 2008, 1086-1124.

    10. Klintworth GK Ataxia telaniectasia; image courtesy of EyePathologist.com. http://www.eyepathologist.com/disease.asp?IDNUM=302040

    11. Yeo TP, Hruban, RH, Leach SD, Wilentz RE, Sohn TA, Kern SE, Iacobuzio-Donahue CA, Maitra A, Groggins M, Canto MI, Abrams RA, Laheru D, Jaffee EM, Hidalgo M, Yeo CJ Pancreatic Cancer Current Problems in Cancer 26(4), 2002, pp 176-225.

      11b.  Willenz RE Goggins M Redston M Marcus VA Adsay NV Sohn TA Kadkol SS Yeo CJ Chota M Zahurak M Johnson K Tascilar M Offerhaus GJA Hruban RH Kern SE Genetic, immunohistochemical, and clinical freatures of medullary carcinoma of the pancreas:  a newly described and characterized entity.  Am J Pathol. 156(5):  1641-1651.  May 2000.

      11c.  Hellerhoff  Intraductal papillary mucinous neoplasm in magnetic resonance imaging. http://en.wikipedia.org/wiki/File:IPMN_T2w_ax-07_a.jpg .

    12. The David G. Jagelman Inherited Colorectal Cancer Registries, Cleveland Clinic, http://www.clevelandclinic.org/registries/inherited/hnpcc.htm.

    13. EUS Imaging http://www.eusimaging.com/main_pancreas_index.html

    14. Endoscopic Ultrasound, Mayo Clinic http://www.mayoclinic.org/endoscopic-ultrasound/

    15. ERCP (Endoscopic Retrograde Cholangiopancreatograpy) National Digestive Diseases Information Clearing House (NDDIC), A service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH), http://digestive.niddk.nih.gov/ddiseases/pubs/ercp/ and more generally www.digestive.niddk.nih.gov .

    16. A.D.A.M resource:  Medical Encyclopedia, http://www.nlm.nih.gov/medlineplus/ency/imagepages/19564.htm .

    17. Endoscopic retrograde cholangiopancreatography (ERCP) University of Wisconsin-Madision, General Surgery, http://www.surgery.wisc.edu/general/patients/uwmhpsercp.shtml

    18. Canto MI, Goggins M, Hruban RH, Petersen GM, Giardiello FM, Yeo C, Fishman EK, Brunne K, Axilbund J, Griffin C, Ali S, Richman J, Janannath S, Kantsevoy SV, Kallo AN. Screening for early pancreatic neoplasia in high-risk individuals:  a prospective controlled study. Clin Gastroenterol Hepatol. 2006 June; 4(6):  766-781.

    19. He T-C, Sparks AB, Rago C, Hermeking H, Zawel L, Da Costa LT, Morin PJ, Vogelstein B, Kinzler KW Identification of c-MYC as a Target of the APC Pathway, Science 4 September 1998, Vol 281, no. 5362, pp 1509-1512.

    20. Pancreaticoblastoma (a.k.a. infantile pancreatic carcinoma) Path Consult http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70444-2 .

     

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