Tumor Suppressor genes (Knudson, 1993)


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RB1sarcoma, retinoblastoma (neurorectodermal)
WT1Wilms tumor (sarcoma)
p53sarcoma, glioma
NF1sarcoma, glioma
VHLpheochromocytoma (endocrine), kidney (carcinoma)
APCcolon (carcinoma)
NB1neuroblastoma (neuroectodermal)
MLMmelanoma (neuroectodermal)
MEN1pituitary adenoma
BCNSmedulloblastoma, skin (carcinoma)
RCCkidney (carcinoma)
BRCA1breast, ovary (carcinoma)