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Etoposide (Vepesid, Toposar, Etopophos) and Teniposide (Vumon)

Mayapple (Berberidaceae)
 

Etoposide

 

Teniposide

 

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References 

  1. Chabner BA, Amrein PC, Bruker BJ, Michaelson MD, Mitsiades CS, Goss PE, Ryan DP, Ramachandra S, Richardson PG, Supko JG, Wilson WH, Antineoplastic Agents in Section IX Chemotherapy of Neoplastic Diseases, Chapter 51 in Goodman & Gilman's The Pharmacological Basis of Therapeutics, 11th edition, (Brunton LL (editor), Laso JS, Parker KL (assoc.eds), McGraw-Hill Medical Publishing Division, New York, 2006, pp1359-1361.
  2. McDowell, T, Podophyllum peltatum L. (Mayapple), family Berberidaceae; this example found in the Pisgah National Forest; http://faculty.etsu.edu/mcdowelt/App Flora Web Plantlist 2004.htm
  3. Baldwin EL Osheroff N Curr Med Chem Anticancer Agents 2005 Jul; 5(4) 363-72.

  4. Holden, JA DNA Topoisomerases as Anticancer Drug Targets:  From the Laboratory to the Clinic  http://www.bentham.org/cmcaca/sample/cmcaca1-1/holden/holden-ms.htm .

    1. Burden DA Osheroff N Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme Biochimica et Biophysica Acta (BB)-Gene Structure and Expresssion 1400, issues 1-3, October 1998, pp. 139-154.
  5. Bender, RP, Jablonsky MJ, Shadid M, Romaine I, Dunlap N, Anklin C, Graves DE, Osheroff N Substituents on Etoposide That Interact with Human Topoisomerase IIα in the Binary Enzyme-Drug Complex:  Contributions to Etoposide Binding and Activity. Biochemistry 2008, 47, 4501-4509.
  6. Etoposide--Drug information provided by Gold Standard (http://www.goldstandard.com/about.htm)
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